Method for rapidly synthesizing nitrobenzimidazole derivative through enzyme catalysis

The invention discloses a method for rapidly synthesizing a nitrobenzimidazole derivative through enzyme catalysis. The method is as follows: taking 6-nitrobenzimidazole and an acrylate compound at the molar ratio of 1 to 1-5 as the raw materials, using lipase Lipozyme RM IM as the catalyst and a DMSO (dimethylsulfoxide) solvent as a reaction solvent, evenly filling the lipase Lipozyme RM IM in areaction channel of a microfluidic channel reactor, wherein the inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4 mm, and the length of the reaction channel is 0.5-1 m; continuously introducing the raw materials and the reaction solvent into the reaction channel to implementing an Michael addition reaction, controlling the reaction temperature of the Michael addition reaction to 40-55 DEG C, controlling the reaction time of the Michael addition reaction to 25-40 minutes, collecting a reaction liquid online, and conventionally processing the reaction liquid,so as to the nitrobenzimid