Method for preparing alcohol compound through uncatalyzed reaction of aromatic carboxylic acid

The invention discloses a method for preparing alcohol compound through uncatalyzed reaction of aromatic carboxylic acid. The method includes: in an inert gas atmosphere, well stirring and mixing pinacolborane and carboxylic acid in a reaction bottle after dehydration deoxygenation, allowing reaction for 6-12h to obtain borate, and further hydrolyzing into alcohol, wherein the carboxylic acid is benzoic acid, 4-bromobenzoic acid, 4-fluorobenzoic acid, 1-naphthoic acid and 2-methoxybenzoic acid. The carboxylic acid is utilized to be in hydroboration reaction with borane efficiently in a catalyst-free condition for the first time, and a carbonyl compound is enabled to be in hydroboration reaction with borane to prepare borate which is further hydrolyzed into alcohol, in this way, a new scheme is provided. 本发明公开了种由芳香族羧酸的无催化反应制备醇化合物的方法。惰性气体氛围中，在经过脱水脱氧处理的反应瓶中将频哪醇硼烷和羧酸搅拌混合均匀，反应6-12小时后得到硼酸酯，进步水解为醇；所述羧酸为苯甲酸、4-溴苯甲酸、4-氟苯甲酸、1-萘甲酸、2-甲氧基苯甲酸等。本发明首次在无催化剂条件下利用羧酸高效地与硼烷发生硼氢化反应，为羰基化合物与硼烷发生硼氢化反应制备硼酸酯，进步水解为醇，提供了新的方案。