Preparation method of polymer tissue engineering stent effectively loaded with heparin and polymer tissue engineering stent thereof

The invention belongs to the field of tissue engineering stents, and discloses a preparation method of a polymer tissue engineering stent effectively loaded with heparin. The preparation method comprises the following steps of (1) dissolving a polymer into a good solvent, so as to prepare a polymer...

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Hauptverfasser: REN CUIHONG, HAN SHANSHAN, WANG XIAOFENG, CHANG ZHONGHUA, MENG XIN, LI XUYAN, WANG DONGFANG, GUO XIN, LI MENGDE, LYU ZIRUI, HOU JIANHUA, LI QIAN, JIANG JING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of tissue engineering stents, and discloses a preparation method of a polymer tissue engineering stent effectively loaded with heparin. The preparation method comprises the following steps of (1) dissolving a polymer into a good solvent, so as to prepare a polymer solution; (2) dissolving the heparin into a water-containing organic solvent mixed with the good solvent in step (1), so as to obtain a heparin solution; (3) uniformly mixing the polymer solution and the heparin solution to obtain a mixed electrostatic spinning solution, putting the mixed electrostatic spinning solution into an injector to perform electrostatic spinning, and receiving by a receiving device which rotates at high speed, so as to obtain the oriented-arrangement type polymer tissueengineering stent loaded with the heparin. The preparation method has the advantages that the spinnability of the mixed electrostatic spinning solution mixed by the heparin and the polymer is improved, the fiber film with goo