METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND

METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND

The invention discloses a method for manufacturing a 7alpha-alkoxyoxacephem intermediate compound and the intermediate compound. The method and the intermediate compound are characterized in that themethod includes, after a step S1 of reacting a compound represented by a following chemical formula 1...

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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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description The invention discloses a method for manufacturing a 7alpha-alkoxyoxacephem intermediate compound and the intermediate compound. The method and the intermediate compound are characterized in that themethod includes, after a step S1 of reacting a compound represented by a following chemical formula 1 with a halogen compound, metal alkoxide and a reducing agent in an organic solvent, a step S2 or astep S3 of performing a continuous reaction with an acetamido gasifying agent or a thioalcohol agent to generate a compound shown as following chemical formula 3 or chemical formula 5; and a simple preparation process, easy batch production and a high yield are achieved. The formulae are shown in the description, wherein R is Cl, Br, I and halogen derivatives; R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H); and R2 is an alkyl group having 1 to 4 carbon atoms. 本发明公开7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物。本发明的7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物的特征在于，包括步骤S2或步骤S3，在有机溶剂中，使由化学式1表示的化合物与卤素化
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The formulae are shown in the description, wherein R is Cl, Br, I and halogen derivatives; R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H); and R2 is an alkyl group having 1 to 4 carbon atoms. 本发明公开7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物。本发明的7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物的特征在于，包括步骤S2或步骤S3，在有机溶剂中，使由化学式1表示的化合物与卤素化</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20190319&amp;DB=EPODOC&amp;CC=CN&amp;NR=109485659A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20190319&amp;DB=EPODOC&amp;CC=CN&amp;NR=109485659A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM DONGAN</creatorcontrib><title>METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND</title><description>The invention discloses a method for manufacturing a 7alpha-alkoxyoxacephem intermediate compound and the intermediate compound. The method and the intermediate compound are characterized in that themethod includes, after a step S1 of reacting a compound represented by a following chemical formula 1 with a halogen compound, metal alkoxide and a reducing agent in an organic solvent, a step S2 or astep S3 of performing a continuous reaction with an acetamido gasifying agent or a thioalcohol agent to generate a compound shown as following chemical formula 3 or chemical formula 5; and a simple preparation process, easy batch production and a high yield are achieved. 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The method and the intermediate compound are characterized in that themethod includes, after a step S1 of reacting a compound represented by a following chemical formula 1 with a halogen compound, metal alkoxide and a reducing agent in an organic solvent, a step S2 or astep S3 of performing a continuous reaction with an acetamido gasifying agent or a thioalcohol agent to generate a compound shown as following chemical formula 3 or chemical formula 5; and a simple preparation process, easy batch production and a high yield are achieved. The formulae are shown in the description, wherein R is Cl, Br, I and halogen derivatives; R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H); and R2 is an alkyl group having 1 to 4 carbon atoms. 本发明公开7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物。本发明的7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物的特征在于，包括步骤S2或步骤S3，在有机溶剂中，使由化学式1表示的化合物与卤素化</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND
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