METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND

The invention discloses a method for manufacturing a 7alpha-alkoxyoxacephem intermediate compound and the intermediate compound. The method and the intermediate compound are characterized in that themethod includes, after a step S1 of reacting a compound represented by a following chemical formula 1 with a halogen compound, metal alkoxide and a reducing agent in an organic solvent, a step S2 or astep S3 of performing a continuous reaction with an acetamido gasifying agent or a thioalcohol agent to generate a compound shown as following chemical formula 3 or chemical formula 5; and a simple preparation process, easy batch production and a high yield are achieved. The formulae are shown in the description, wherein R is Cl, Br, I and halogen derivatives; R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H); and R2 is an alkyl group having 1 to 4 carbon atoms. 本发明公开7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物。本发明的7α-烷氧基氧头孢烯中间体的制备方法及中间体化合物的特征在于，包括步骤S2或步骤S3，在有机溶剂中，使由化学式1表示的化合物与卤素化