Novel synthesis method for oxophenylacetate

The invention discloses a novel synthesis method for oxophenylacetate and belongs to the technical field of synthesis. The novel synthesis method comprises the steps: firstly, reacting benzonitrile and a halogenation reagent at 20-35 DEG C to obtain dihalogenated phenylacetonitrile; then, adding a m...

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1. Verfasser: LI KUNWU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a novel synthesis method for oxophenylacetate and belongs to the technical field of synthesis. The novel synthesis method comprises the steps: firstly, reacting benzonitrile and a halogenation reagent at 20-35 DEG C to obtain dihalogenated phenylacetonitrile; then, adding a mixed solution of acid and water into dihalogenated phenylacetonitrile at 35-55 DEG C, and carrying out a reaction at 50-60 DEG C for 2-8 h, wherein the molar ratio of a product I to the water to the acid is 1:(1-10):(1-10); and finally, adding alcohol into the reaction solution in the former step at50-60 DEG C, then, carrying out stirring, controlling the temperature at 60-70 DEG C, carrying out a constant-temperature reaction for 1-4 h, and carrying out cooling and extraction to obtain a target product. The reaction raw materials adopted in the method are wide in source and low in price, the operation process is simple, and the yield of the product is high. 本发明公开了种氧代苯乙酸酯的新合成方法,属于合成技术领域。该方法步骤为:首先将苄腈和卤化试剂在20~35℃下反应得