METHODS AND COMPOSITIONS FOR ANTICANCER THERAPIES THAT TARGET MENA PROTEIN ISOFORMS KINASES

Phosphorylation and dephosphorylation of MENA and MENA isoforms regulates the metastatic activity of cancer cells. Administration of a MENA kinase inhibitor results in significant reduction in the development of cancer metastasis in established and developing tumors. Administration of a MENA kinase inhibitor in conjunction with a tyrosine kinase inhibitor enhances efficacy of tyrosine kinase inhibitor therapy. Administration of a MENA kinase inhibitor in conjunction with anti-microtubule agent results in significant reduction in chemotherapy-induced tumor cell dissemination and enhances efficacy of anti-microtubule therapy. MENA和MENA同种型的磷酸化和去磷酸化调控癌细胞的转移活性。MENA激酶抑制剂的施用使得已建立且正在发展的肿瘤中的癌症转移的发展显著减少。与酪氨酸激酶抑制剂结合施用MENA激酶抑制剂增强酪氨酸激酶抑制剂疗法的功效。与抗微管剂结合施用MENA激酶抑制剂使得化学疗法诱导的肿瘤细胞播散显著减少并增强抗微管疗法的功效。