Environment-friendly method for synthesizing clevudine drug intermediate

The invention relates to an environment-friendly method for synthesizing a clevudine drug intermediate. The method comprises the following the steps: according to formulas shown in the specification,dissolving the compound of formula II in an organic solvent, adding 40% hydrobromic acid and tetrabut...

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Bibliographische Detailangaben
Hauptverfasser: DING BANGDONG, CHEN TAO, MA ZHENXIONG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to an environment-friendly method for synthesizing a clevudine drug intermediate. The method comprises the following the steps: according to formulas shown in the specification,dissolving the compound of formula II in an organic solvent, adding 40% hydrobromic acid and tetrabutylammonium fluoride under an ice bath, stirring for 3 hours, adding triethylamine trihydrofluoride,and continuously stirring for 3 to 4 hours to obtain the compound of formula I. 本发明涉及种绿色合成克拉夫定药物中间体的方法,包括如下步骤:将式II化合物溶于有机溶剂中,冰浴下加入40%的氢溴酸、四丁基氟化铵,搅拌反应3小时后,加入三乙胺三氢氟酸盐,继续搅拌反应3-4小时,即得式I化合物。