Benzimidazole derivative and preparation method and application as medicine thereof
The invention relates to a novel benzimidazole PPAR alpha/gamma/delta panto-agonist as shown in the general formula (I) and a preparation method thereof and application of a medicine compound containing the derivative in preparing a medicine for preventing or/and treating abnormal glucose metabolism...
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| creator | LI ZHENG LIU ROUJIA ZHANG LUYONG |
| description | The invention relates to a novel benzimidazole PPAR alpha/gamma/delta panto-agonist as shown in the general formula (I) and a preparation method thereof and application of a medicine compound containing the derivative in preparing a medicine for preventing or/and treating abnormal glucose metabolism or/and abnormal lipids metabolism disease. The PPAR alpha/gamma/delta panto-agonist has excellent in-vivo hypoglycemic activity and blood fat adjusting action, can be applied for preparing medicines for preventing or/and treating metabolic syndrome related diseases of diabetes, obesity, hyperlipidemia, atherosclerosis, fatty liver and the like, and has wide application prospects.
本发明涉及类通式(I)所示的新型苯并咪唑类PPARα/γ/δ泛激动剂、其制备方法及含有该衍生物的药物组合物作为制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物用途。所述的PPARα/γ/δ泛激动剂具有优异的体内降血糖活性及调节血脂作用，可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化及脂肪肝等代谢综合症相关疾病的药物，具有广阔的应用前景。 |
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本发明涉及类通式(I)所示的新型苯并咪唑类PPARα/γ/δ泛激动剂、其制备方法及含有该衍生物的药物组合物作为制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物用途。所述的PPARα/γ/δ泛激动剂具有优异的体内降血糖活性及调节血脂作用，可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化及脂肪肝等代谢综合症相关疾病的药物，具有广阔的应用前景。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190312&DB=EPODOC&CC=CN&NR=109456274A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190312&DB=EPODOC&CC=CN&NR=109456274A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI ZHENG</creatorcontrib><creatorcontrib>LIU ROUJIA</creatorcontrib><creatorcontrib>ZHANG LUYONG</creatorcontrib><title>Benzimidazole derivative and preparation method and application as medicine thereof</title><description>The invention relates to a novel benzimidazole PPAR alpha/gamma/delta panto-agonist as shown in the general formula (I) and a preparation method thereof and application of a medicine compound containing the derivative in preparing a medicine for preventing or/and treating abnormal glucose metabolism or/and abnormal lipids metabolism disease. The PPAR alpha/gamma/delta panto-agonist has excellent in-vivo hypoglycemic activity and blood fat adjusting action, can be applied for preparing medicines for preventing or/and treating metabolic syndrome related diseases of diabetes, obesity, hyperlipidemia, atherosclerosis, fatty liver and the like, and has wide application prospects.
本发明涉及类通式(I)所示的新型苯并咪唑类PPARα/γ/δ泛激动剂、其制备方法及含有该衍生物的药物组合物作为制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物用途。所述的PPARα/γ/δ泛激动剂具有优异的体内降血糖活性及调节血脂作用，可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化及脂肪肝等代谢综合症相关疾病的药物，具有广阔的应用前景。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh2Ss2ryszNTEmsys9JVUhJLcosSyzJLEtVSMxLUSgoSi1ILALy8_MUclNLMvJTwMKJBQU5mckQ4cRioExKZnJmXqpCSUZqUWp-Gg8Da1piTnEqL5TmZlB0cw1x9tBNLciPTy0uSExOzUstiXf2MzSwNDE1MzI3cTQmRg0Aq-85BQ</recordid><startdate>20190312</startdate><enddate>20190312</enddate><creator>LI ZHENG</creator><creator>LIU ROUJIA</creator><creator>ZHANG LUYONG</creator><scope>EVB</scope></search><sort><creationdate>20190312</creationdate><title>Benzimidazole derivative and preparation method and application as medicine thereof</title><author>LI ZHENG ; LIU ROUJIA ; ZHANG LUYONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109456274A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI ZHENG</creatorcontrib><creatorcontrib>LIU ROUJIA</creatorcontrib><creatorcontrib>ZHANG LUYONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI ZHENG</au><au>LIU ROUJIA</au><au>ZHANG LUYONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Benzimidazole derivative and preparation method and application as medicine thereof</title><date>2019-03-12</date><risdate>2019</risdate><abstract>The invention relates to a novel benzimidazole PPAR alpha/gamma/delta panto-agonist as shown in the general formula (I) and a preparation method thereof and application of a medicine compound containing the derivative in preparing a medicine for preventing or/and treating abnormal glucose metabolism or/and abnormal lipids metabolism disease. The PPAR alpha/gamma/delta panto-agonist has excellent in-vivo hypoglycemic activity and blood fat adjusting action, can be applied for preparing medicines for preventing or/and treating metabolic syndrome related diseases of diabetes, obesity, hyperlipidemia, atherosclerosis, fatty liver and the like, and has wide application prospects.
本发明涉及类通式(I)所示的新型苯并咪唑类PPARα/γ/δ泛激动剂、其制备方法及含有该衍生物的药物组合物作为制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物用途。所述的PPARα/γ/δ泛激动剂具有优异的体内降血糖活性及调节血脂作用，可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化及脂肪肝等代谢综合症相关疾病的药物，具有广阔的应用前景。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Benzimidazole derivative and preparation method and application as medicine thereof |
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