Benzimidazole derivative and preparation method and application as medicine thereof

The invention relates to a novel benzimidazole PPAR alpha/gamma/delta panto-agonist as shown in the general formula (I) and a preparation method thereof and application of a medicine compound containing the derivative in preparing a medicine for preventing or/and treating abnormal glucose metabolism or/and abnormal lipids metabolism disease. The PPAR alpha/gamma/delta panto-agonist has excellent in-vivo hypoglycemic activity and blood fat adjusting action, can be applied for preparing medicines for preventing or/and treating metabolic syndrome related diseases of diabetes, obesity, hyperlipidemia, atherosclerosis, fatty liver and the like, and has wide application prospects. 本发明涉及类通式(I)所示的新型苯并咪唑类PPARα/γ/δ泛激动剂、其制备方法及含有该衍生物的药物组合物作为制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物用途。所述的PPARα/γ/δ泛激动剂具有优异的体内降血糖活性及调节血脂作用，可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化及脂肪肝等代谢综合症相关疾病的药物，具有广阔的应用前景。