Production method of trimecaine monohydrochloride

The invention discloses a production method of trimecaine monohydrochloride. According to the production method, raw materials, namely 2,4,6-trimethylaniline, chloroacetyl chloride and diethylamine, are adopted for reaction, the liquid phase purity of an obtained product is 99.9% or above, and the t...

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Hauptverfasser: FAN KEJUN, YU WEIQIANG, WANG TINGJIAN, WANG ZHIGANG, WANG YONGGUANG, ZHAO ZHONGGUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a production method of trimecaine monohydrochloride. According to the production method, raw materials, namely 2,4,6-trimethylaniline, chloroacetyl chloride and diethylamine, are adopted for reaction, the liquid phase purity of an obtained product is 99.9% or above, and the total yield reaches 90% or above. The production method of the trimecaine monohydrochloride has the advantages of short production cycle, easy operation, low cost and high yield, in addition,, intermediate solvent recovery in the production method can be used indiscriminately, and the safer and moreenvironmentally friendly effects are achieve; and the production method is suitable for industrial production. 本发明公开了种盐酸三甲卡因的生产方法。该方法采用原料均三甲基苯胺、氯乙酰氯、二乙胺进行反应,得到产品液相纯度在99.9%以上,总收率达到90%以上。本发明盐酸三甲卡因的生产方法有生产周期短、操作简单、成本低、收率高的优点,另外本生产方法中间体溶剂回收可以进行套用,更加的安全和环保;适合于工业化生产。