Application of optineurin protein in preparing acute hepatic damage diagnosis and treatment products

The invention provides application of optineurin protein in preparing acute hepatic damage diagnosis and treatment products. Experiments prove that the OPTN (optineurin) protein is increased in protein in acute hepatic damage tissues and relieves polarization of macrophages through autophagy to release acute hepatic damage, and accordingly acute hepatic damage can be relieved by expressing the OPTN protein or applying bavachinin. Therefore, the OPTN protein can serve as a specific marker protein for diagnosis and drug therapy of acute hepatic damage, and through the agonist of the bavachinin and overexpression viruses, effectively treats acute hepatic damage to achieve more accurate and quicker diagnosis and treatment of acute hepatic damage. The optineurin protein provides a new therapeutic target and an effective new drug for treating acute hepatic damage. 本发明提供种optineurin蛋白在制备诊断和治疗急性肝损伤药物中的应用。本发明实验证明OPTN蛋白在急性肝损伤组织中表达升高，其通过自噬缓解巨噬细胞的极化来缓解急性肝损伤，并且过表达OPTN蛋白或者使用补骨脂二氢黄酮甲醚可以缓解急性肝损伤。因此，OPTN蛋白可作为诊断和采用药物治疗急性肝损伤的特异性标