Erythrocyte membrane-encapsulated tetrandrine PLGA nanoparticle and preparation method and application thereof

The invention belongs to the technical field of pharmacy and particularly relates to an erythrocyte membrane-encapsulated tetrandrine PLGA nanoparticle and a preparation method and application thereof. The nanoparticle structurally includes an erythrocyte membrane, PLGA and tetrandrine, the tetrandrine is combined with PLGA to form a tetrandrine-PLGA nanocore, and the erythrocyte membrane is encapsulated outside the tetrandrine-PLGA nanocore. The preparation method is simple and efficient. The nano preparation improves the biocompatibility of a whole drug delivery system, long circulation andsustained release of the tetrandrine in the human body are achieved, toxic and side effects caused by too high blood medicine peak concentration of common injections are avoided, and the nanoparticlehas a good application prospect. 本发明属于制药技术领域，具体涉及种红细胞膜包封的粉防己碱PLGA纳米粒及其制备方法与应用。所述纳米粒的结构中包括红细胞膜、PLGA和粉防己碱，所述粉防己碱和所述PLGA结合形成粉防己碱-PLGA纳米核，所述红细胞膜包封于所述粉防己碱-PLGA纳米核外部。所述制备方法简便高效。该纳米制剂提高了整个药物输送体系的生物相容性，实现了粉防己碱在体内的长循环和缓释，避免了普通注射剂的血药峰浓度