Valsartan amlodipine compound tablet and preparation method thereof

The invention relates to a valsartan amlodipine compound tablet and a preparation method thereof. The compound tablet is prepared from, by weight, 40-160 parts of valsartan, 5-10 parts of amlodipine besylate, 30-80 parts of filler, 8-35 parts of cross-linked polyvinylpolypyrrolidone, 0.5-5 parts of colloidal silicon dioxide and 1-10 parts of magnesium stearate. The valsartan amlodipine compound tablet is relatively stable in dissolubility, and as time goes on in a shelf period, dissolubility decline is evidently reduced, and pharmaceutical effectiveness is guaranteed. 本发明涉及了种缬沙坦氨氯地平复方片剂及其制备方法。具体而言，所述复方片剂由以下重量份的组分制成：缬沙坦40-160份，苯磺酸氨氯地平5-10份，填充剂30-80份，交联聚维酮8-35份，胶体二氧化硅0.5-5份，硬脂酸镁1-10份。本发明的缬沙坦氨氯地平复方片剂的溶出度相对稳定，在货架期内随着时间的推移，溶出度的下降幅度明显减小，保证用药的有效性。