Application of RPSS27 and/C16orf89 in preparing diagnostic preparation of osteoarthritis

The invention provides an application of a preparation of a RPSS27 and/C16orf89 gene and an expression product thereof in preparing a diagnostic preparation of osteoarthritis. The inventor screens theRPSS27 and C16orf89 genes based on a high-throughput sequencing result, and further verifies a low e...

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Hauptverfasser: YE WEILIANG, JIA BINGHAN, YANG YUEMEI
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creator YE WEILIANG
JIA BINGHAN
YANG YUEMEI
description The invention provides an application of a preparation of a RPSS27 and/C16orf89 gene and an expression product thereof in preparing a diagnostic preparation of osteoarthritis. The inventor screens theRPSS27 and C16orf89 genes based on a high-throughput sequencing result, and further verifies a low expression result of the RPSS27 and/C16orf89 gene in osteoarthritis tissues through a molecular biology method. An agonist thereof can be used for preparing a drug for treating osteoarthritis. The invention provides a novel treatment target for osteoarthritis and has important clinical application value. 本发明提供了检测PRSS27和/或C16orf89基因及其表达产物的制剂在制备骨性关节炎诊断制剂中的应用;发明人基于高通量测序结果筛选出PRSS27和C16orf89基因,进步,通过分子生物学方法验证,证实了PRSS27和/或C16orf89基因在骨性关节炎组织中低表达的结果,其激动剂可用于制备治疗骨性关节炎药物。本发明提供了种新的骨性关节炎的治疗靶点,具有重要的临床应用价值。
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language chi ; eng
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
title Application of RPSS27 and/C16orf89 in preparing diagnostic preparation of osteoarthritis
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