Method for preparing alcoholic compound from anilino lithium compound as catalyst

The invention relates to an application of an anilino lithium compound, in particular to a method for preparing an alcoholic compound from the anilino lithium compound as a catalyst. The catalyst, borane and carboxylic acid are stirred and mixed uniformly, subjected to a reaction and exposed to air...

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Hauptverfasser: CAI LINGXIA, SHEN QI, CHEN SUFANG, XUE MINGQIANG, YAN DANDAN, XU XIAOJUAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to an application of an anilino lithium compound, in particular to a method for preparing an alcoholic compound from the anilino lithium compound as a catalyst. The catalyst, borane and carboxylic acid are stirred and mixed uniformly, subjected to a reaction and exposed to air to terminate the reaction, a reacted liquid is subjected to reduced-pressure treatment for solvent removal, silica gel and methanol are added, and the alcoholic compound is obtained by hydrolysis. The anilino lithium compound can perform high-activity catalysis on the reaction between carboxylic acid and borane at room temperature, dose of the catalyst is only 0.8mol% of the mole ratio of carboxylic acid, compared with the conventional catalysis system, the commercial reagent anilino lithium compound is used, reaction conditions are mild, and yield of borate with different substituents under limit conditions can reach 90% or higher. 本发明涉及苯胺基锂化合物的应用,具体涉及利用苯胺基锂化合物为催化剂制备醇化合物的方法,依次将催化剂、硼烷和羧酸搅拌混合均匀,反应后暴露于空气中终止反应,反应液减压除去