Preparation method of 1-ethyl-(3-dimethyl amino propyl) carbodiimide hydrochloride

The invention relates to a preparation method of 1-ethyl-(3-dimethyl amino propyl) carbodiimide hydrochloride and belongs to the technical field of medicine intermediates. The preparation method comprises the following seven steps: carrying out a reaction to generate EDTC; preparing an EITC coarse product; carrying out distillation and fractionation; preparing an intermediate; preparing EDC; and preparing a target product. The preparation method provided by the invention has the characteristics of being high in product yield and purity, simple in operating step, easy to implement and suitablefor industrial production. 本发明涉及种1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐的制备方法，属于医药中间体技术领域。所述的制备方法包含反应生成EDTC、制得EITC粗品、蒸馏分馏、制得中间体、制得EDC和制得目标产物等七个步骤。本发明所提供的制备方法，具有高的产品收率和纯度，操作步骤简单，易于实施，适合工业化生产的特点。