Eosinophilic bronchitis mouse model establishing and detecting method

The invention discloses an eosinophilic bronchitis mouse model establishing and detecting method. The method includes steps: (1) subjecting a mouse to OVA sensitization and stimulation to establish aneosinophilic bronchitis mouse model; (2) allowing the mouse obtained in the step (1) to freely move in an airtight plethysmographic chamber of a Buxco noninvasive lung function detecting system in connection with an atomizing controller and a signal converter; (3) stimulating the mouse by methacholine atomizing, and assessing bronchial reactivity of the mouse according to changes of Penh values determined through a bronchial reactivity mode of Finepointe software before and after atomizing stimulation of the mouse. The mouse EB (eosinophilic bronchitis) model with characteristics of evident cough, no airway hyperresponsiveness, airway eosinophilic inflammation and effective homonotherapy is ethically established, and popularization and application of the mouse EB model are benefited. 本发明公开了种嗜酸粒细胞性支气管炎小鼠模型的建立和检测方法