Preparation method of composite trelagliptin succinate tablets

The invention provides a preparation method of composite trelagliptin succinate tablets. Preparation of trelagliptin succinate raw materials comprises the step of separately sieving 50 g-230 g of trelagliptin succinate raw materials, 300 g-1380 g of apocynum venetum plaster powder, 30 g-86 g of mannitol, 2 g-58 g of microcrystalline celluloses, 1.8 g-37 g of croscarmellose sodium and 3.2 g-54 g ofsodium stearyl fumarate by using a sieve with meshes of 60, wherein the trelagliptin succinate raw materials and the apocynum venetum plaster powder are added according to the ratio of 1: (5-7), theuse amount of drugs and the toxic and side effects of the drugs are reduced obviously, and an effect of treating diabetes is remarkable. 本发明提供种复合琥珀酸曲格列汀片制备方法，琥珀酸曲格列汀原料的制备，然后将琥珀酸曲格列汀原料50g-230g、罗布麻膏粉300g-1380g、甘露醇30g-86g、微晶纤维素2g-58g、交联羧甲基纤维素钠1.8g-37g以及硬脂富马酸钠3.2g-54g分别过60目筛网，其中：琥珀酸曲格列汀原料与罗布麻膏粉按1∶(5-7)加入，明显减少药物用量和药物的毒副作用，治疗糖尿病症效果显著。