VORTIOXETINE DOSING REGIMES FOR FAST ONSET OF ANTIDEPRESSANT EFFECT

A dose regimen comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma levelachieved by the administration to said patient of said first composition alone. 本发明涉及包括同时给予两种药物组合物的剂量方案，其中第药物组合物是用于每日次口服给药的包含沃替西汀或其药学上可接受的盐的组合物，并且第二药物组合物是包含沃替西汀或其药学上可接受的盐的组合物，该第二药物组合物与所述第组合物起在所述患者体内快速达到沃替西汀的稳态血浆水平，该稳态血浆水平与通过向所述患者单独给予所述第组合物所达到的稳态沃替西汀血浆水平相同。