Di(hetero)arylmethanol compound preparation method

The invention belongs to the field of organic synthesis, and particularly relates to a di(hetero)arylmethanol compound preparation method, wherein the di(hetero)arylmethanol compound is prepared in ahigh-yield manner by using commercially available (hetero)aryl aldehyde and commercially available (h...

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Hauptverfasser: YANG LIANMING, CHEN QIANG, FAN XINHENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of organic synthesis, and particularly relates to a di(hetero)arylmethanol compound preparation method, wherein the di(hetero)arylmethanol compound is prepared in ahigh-yield manner by using commercially available (hetero)aryl aldehyde and commercially available (hetero)arylboronic acid as raw materials and using a cheap and stable divalent nickel source as a catalyst. According to the present invention, the method improves the shortcomings of harsh reaction conditions, more side reactions, difficult post-treatment and the like caused by the general use of metal reagents, avoids the defects of high cost of catalytic reactions of noble metals such as palladium and the like and difficulty in mass production, has characteristics of mild conditions, convenient operation, low cost, high efficiency and environmental friendliness, and is suitable for practical scale production. 本发明属于有机合成领域,具体涉及二(杂)芳基甲醇类化合物的制备方法。本发明的方法是以市场可得的(杂)芳基醛与(杂)芳基硼酸为原料、廉价稳定的二价镍源为催化剂高收率地制备二(杂)芳基甲醇类化合物。本发明的方法改善