Ferric citrate dosage forms

The disclosure relates to ferric citrate tablets and dosage forms, and particularly relates to: a tablet comprising granules comprising ferric citrate and a binder, wherein the tablet has an average surface area mass ratio equal to or greater than 1 square meter per gram. A method for preparing the...

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1. Verfasser: LE HENRY TRONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The disclosure relates to ferric citrate tablets and dosage forms, and particularly relates to: a tablet comprising granules comprising ferric citrate and a binder, wherein the tablet has an average surface area mass ratio equal to or greater than 1 square meter per gram. A method for preparing the tablet includes: mixing ferric citrate with one or more binders to form ferric citrate particles under conditions where the LOD of water does not exceed 25%, shaping the ferric citrate particles into ingots to shape the tablets. A method for preventing or treating hyperphosphatemia by feeding such tablets is also provided. 本发明涉及柠檬酸铁剂型,并且具体涉及:种包含颗粒的片剂,该片剂包含柠檬酸铁及黏合剂,其中该片剂的平均表面积质量比等于或大于1平方米/公克;种制备上述片剂的方法,该方法包含:在水的LOD%不超过25%的条件下,使柠檬酸铁与或多种黏合剂混合形成柠檬酸铁颗粒,将该柠檬酸铁颗粒制锭以形成片剂;以及种预防或治疗高磷酸盐血症的方法,其包含投予上述片剂。