METHODS FOR SYNTHESIZING ALPHA4BETA7 PEPTIDE ANTAGONISTS

The present invention provides methods of making alpha4beta7 peptide monmer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesisvia condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues. 本发明提供了制备α4β7肽单体和二聚体拮抗剂的方法。本发明的方法包括固相和溶液相方法，以及通过较小肽片段的缩合合成。本发明的方法还包括涉及合成包含个或多个青霉胺残基的肽的方法。