POLYMER-BASED MATERIAL HAVING COVALENTLY BONDED, ENZYMATICALLY DEGRADABLE PEPTIDE SEQUENCES

The invention relates to a polymer-based material having covalently bonded enzymatically degradable peptide sequences which are not degradable by the biological and metabolic activity of cells and tissues, wherein the peptide sequences each consist of two to fifteen amino acids and are incorporated into the polymer-based material or conjugated onto the polymer-based material. The peptide sequencecan accordingly either be part of a three-dimensional or two-dimensional structure of the polymer-based material. By means of an enzyme-addition-controlled degradation of a covalent bond in the peptide sequence either a bioorthogonal degradation of the three-dimensional structure, or in the case of a conjugation of the peptide sequence onto the polymer-based material the liberation of at least a part of the molecule, is effected. The invention further relates to the use of such a polymer-based material for an in vitro production of cell cultures or tissues or organs, for an in vivo stabilization of donated cells, tiss