Preparation method for 1-aryl-4-methoxyformyl-1,2,3-triazole derivative

The invention discloses a preparation method for 1-aryl-4-methoxyformyl-1,2,3-triazole derivative, and belongs to the technical field of medical intermediates and organic synthesis. 1,4-diaryl-1,2,3-triazole is taken as raw materials, under the catalytic action of transition metal, No.4 aryl group is directly converted into methoxyformyl, and the 1-aryl-4-methoxyformyl-1,2,3-triazole derivative isselectively generated; the synthetic compound simultaneously contains the 1,2,3-triazole ring and a methoxyformyl structure unit, and can serve as a transition metal ligand to be applied to catalyticreaction, and a new method is provided for medicine synthesis and modification. 本发明公开种1-芳基-4-甲氧甲酰基-1,2,3-三氮唑衍生物的制备方法，属于医药中间体及有机合成技术领域；本发明以1,4-二芳基-1,2,3-三氮唑为原料，在过渡金属催化作用下使4号位芳基直接转变为甲氧甲酰基，选择性生成1-芳基-4-甲氧甲酰基-1,2,3-三氮唑衍生物；所合成的化合物同时含有1,2,3-三唑环及甲氧甲酰基结构单元，可作为过渡金属配体应用于催化反应，亦为药物的合成与修饰提供了种新方法。