Synthetic method of anastrozole key intermediate

The invention provides a preparation method of an anastrozole key intermediate (I) shown in the description. 3, 5-toluene dihalide (II) and 2-methyl-2-cyanopropionic acid (III) are taken as raw materials and subjected to one-step reaction in the presence of alkali, a solvent and a copper catalyst, and a target product is generated. The method has the advantages of being simple and controllable tooperate, high in product yield, low in cost, environmentally friendly and suitable for large-scale industrial enlarged production. 本发明提供种阿那曲唑关键中间体(I)的制备方法，选用3，5-二卤代甲苯(II)、2-甲基-2-氰基丙酸(III)为原料，在碱、溶剂和铜催化剂条件下，步反应生成目标产物。操作简单可控，产品收率高，成本低，环境友好，适于工业规模化放大生产。