Synthetic method of 2,5-dibromo iodobenzene

The invention discloses a synthetic method of 2,5-dibromo iodobenzene. The synthetic method comprises the following steps: S1, synthesis of 2-nitro-4-bromophenol; S2, synthesis of 2-amido-4-bromophenol; S3, synthesis of 2-iodo-4-bromophenol; S4, synthesis of 2,5-dibromo iodobenzene: putting the 2-io...

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Hauptverfasser: ZHAN HAOSHENG, WANG YU, HU ZHIWEI, FANG ZHONGXUE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a synthetic method of 2,5-dibromo iodobenzene. The synthetic method comprises the following steps: S1, synthesis of 2-nitro-4-bromophenol; S2, synthesis of 2-amido-4-bromophenol; S3, synthesis of 2-iodo-4-bromophenol; S4, synthesis of 2,5-dibromo iodobenzene: putting the 2-iodo-4-bromophenol into a chemical reaction still, then adding a dioxane solvent and stirring at roomtemperature; and gradually adding phosphorus tribromide in the process, and carrying out vacuum fractionation on a reactant and collecting fraction under the conditions of 130 to 140 DEG C and 3.25 to3.45 kPa, thus obtaining the 2,5-dibromo iodobenzene. According to the synthetic method disclosed by the invention, by utilizing p-bromophenol as a raw material, the 2-nitro-4-bromophenol is preparedand further the 2-amido-4-bromophenol is prepared; subsequently the 2-iodo-4-bromophenol is produced and finally the 2,5-dibromo iodobenzene is synthesized, so that the 2,5-dibromo iodobenzene is synthesized in another way and