Inhibitors of indoleamine 2,3-dioxygenase

Inhibitors of indoleamine 2,3-dioxygenase

The invention relates to a compound of Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selectiveinhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of...

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Hauptverfasser: BUIJSMAN ROGIER CHRISTIAN, ZAMAN GUIDO JENNY RUDOLF, DE MAN ADRIANUS PETRUS ANTONIUS, UITDEHAAG JOOST CORNELIS MARINUS, DE WIT JOERI JOHANNES PETRUS, VAN DOORNMALEN ANTONIUS MARIA, SEEGERS NICOLE WILHELMINA CORNELIA, STERRENBURG JAN GERARD
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a compound of Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selectiveinhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous systemdisease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies. 本发明涉及式I的化合物或其药学上可接受的对映异构体或盐。本发明还涉及式(I)的化合物作为吲哚胺2,3-双加氧酶的选择性抑制剂的用途。本发明还涉及式(I)的化合物作为单药剂或与其他疗法组合用于治疗或预防癌症、感染、中枢神经系统疾病或障碍以及免疫相关障碍的用途。