Method of determining or predicting characteristic of cell

A method of determining or predicting a characteristic of a query cell, for example the identity of the query cell, is described. The method comprises the steps of incubating the query cell with a plurality of chemical cell stressor molecules, determining the growth response of the query cell in the...

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Bibliographische Detailangaben
Hauptverfasser: THOMPSON BEN, JAMES DAVID, DAVIES SARAH LOUISE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:A method of determining or predicting a characteristic of a query cell, for example the identity of the query cell, is described. The method comprises the steps of incubating the query cell with a plurality of chemical cell stressor molecules, determining the growth response of the query cell in the presence of each of the at least three chemical cell stressor molecules to generate a query cell-specific growth response fingerprint, and comparing the query cell-specific growth response fingerprint with one or more reference cell-specific growth response fingerprints corresponding to one or morecells having known characteristics. The characteristic of the cell (for example the identity of the cell) may be determined based on the level of correlation between the query cell-specific growth response fingerprint and the one or more reference cell-specific growth response fingerprints. 描述了种确定或预测查询细胞特征,例如查询细胞身份的方法。该方法包括以下步骤:采用多种化学细胞应激原分子培养查询细胞;确定查询细胞在至少三种化学细胞应激原分子中的每种化学细胞应激原分子存在下的生长响应,得到查询细胞-特异性生长响应指纹;将查询细胞-特异性生长响应指纹