Preparation method of intermediate containing halogenated benzene ring side-chain flubendiamide structure
The invention discloses a preparation method of an intermediate containing a halogenated benzene ring side-chain flubendiamide structure, comprising the following steps: adding 3-iodophthalic acid, toluene and p-methylbenzene sulfonic acid to obtain a 3-iodophthalic anhydride solution; adding trieth...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a preparation method of an intermediate containing a halogenated benzene ring side-chain flubendiamide structure, comprising the following steps: adding 3-iodophthalic acid, toluene and p-methylbenzene sulfonic acid to obtain a 3-iodophthalic anhydride solution; adding triethylamine, cooling, dropwise adding a DMAC solution of 2-methyl-1-methylthiopropylamine to obtain 3-iodine-N-(1,1-dimethyl-2-methylthioethyl)carbamoylbenzoic acid and an isomer solution thereof; adding a dilute sulfuric acid solution, heating, and stirring to obtain 3-iodine-N-(1,1-dimethyl-2-methylthioethyl)carbamoylbenzoic acid and an isomer thereof; and adding a hydrochloric acid solution and heating to 60-80 DEG C and then carrying out thermal insulation for 1-3h, completing the hydrolysis ofthe isomer, cooling to 0-20 DEG C, and carrying out suction filtration to obtain the finished product 3-iodine-N-(1,1-dimethyl-2-methylthioethyl) carbamoylbenzoic acid. By the preparation method of the intermediate containing |
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