Preparation method of ceftriaxone sodium powder preparation for injection

Belonging to the technical field of medicine, the invention discloses a preparation method of a ceftriaxone sodium powder preparation for injection. The method includes: firstly adding a first batch of a solvent b into a crystallization tank during crystallization treatment, then slowly adding a crude ceftriaxone sodium solution into the crystallization tank, and then adding a second batch of thesolvent b; wherein the solvent b is any one of acetone, acetonitrile or isopropanol. The preparation process adopted by the invention is simple, and can effectively improve the product quality. The obtained product ceftriaxone sodium crystal has good flowability, is easy for subpackaging and stable in quality, and the color grade, clarity and purity of the product are also improved. 本发明公开了种注射用头孢曲松钠粉针制剂的制备方法，属于医药技术领域，包括结晶处理时先在结晶罐中加入第批溶媒b，然后将头孢曲松钠粗品溶液缓慢加入到结晶罐中，再加入第二批溶媒b；所述溶媒b为丙酮、乙腈或异丙醇中的任种。本发明的制备工艺简单，可有效改善产品的品质，得到的产品头孢曲松钠晶体的流动性好、易于分装，质量稳定，并且提高了产品的色级、澄清度及纯度。