Preparation method of 8-benzyloxy-5-(R-2-bromo-1-hydroxyethyl)-1H-quinoline-2-one

The invention relates to a preparation method of 8-benzyloxy-5-(R-2-bromo-1-hydroxyethyl)-1H-quinoline-2-one; in particular, with 8-benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline being a raw materialand [Ru(II)-(phosphine ligand)(diamine)] being a chiral ligand catalyst, the 8-benzyloxy-5-(R-2-bromo-1-hydroxyethyl)-1H-quinoline-2-one is synthesized high-effectively through catalytic hydrogenation. The preparation method is high in yield and chiral purity, is low in cost, is environment-friendly, is easy to carry and is suitable for industrialization. 本发明涉及8-苄氧基-5-(R-2-溴-1-羟基乙基)-1H-喹啉-2-酮的制备方法，具体涉及以8-苄氧基-5-(2-溴乙酰基)-2-羟基喹啉为原料，以[Ru(II)-(膦配体)(二胺)]为手性配体催化剂，催化氢化高效地合成8-苄氧基-5-(R-2-溴-1-羟基乙基)-1H-喹啉-2-酮；本发明提供的8-苄氧基-5-(R-2-溴-1-羟基乙基)-1H-喹啉-2-酮的制备方法是种高收率、高手性纯度、低成本、环保、易操作、适宜工业化的制备方法。