Synthetic method of aminoisoindole derivatives

The invention belongs to the technical field of organic synthesis chemistry, and particularly relates to a synthetic method of aminoisoindole derivatives. According to the invention, continuous carbon-nitrogen bond construction is catalyzed by rare earth, so that synthesis of aminoisoindole derivatives with diversified structures is realized. Specifically, a compound 2-phenylethynyl benzonitrile and secondary amine are used as raw materials, and the aminoisoindole derivatives are prepared under a rare-earth catalysis system. According to the method disclosed by the invention, the raw materialsare wide in source or are easy to prepare, the operation is simple and convenient, selectivity is controllable, the yield is high, conditions are mild, and universality is wide. 本发明属于有机合成化学技术领域，具体为种氨基异吲哚衍生物的合成方法。本发明通过稀土催化连续的碳-氮键构建从而实现结构多样化的氨基异吲哚衍生物合成。具体是在稀土催化体系下，以化合物2-苯乙炔基苯甲腈与二级胺为原料，制备氨基异吲哚衍生物。本发明方法原料来源广泛或易于制备，操作简便、选择性可控，收率高，条件温和，普适性广。