PHARMACEUTICAL COMPOSITION, PREPARING METHODS AND USES OF THE COMPOSITION

A pharmaceutical composition includes one or a plurality of metal nanoparticles and therapeutic agent. Each of the metal nanoparticles includes a core and a stabilizing agent covering the surface of the core. The therapeutic agent is attached to the stabilizing agent of the metal nanoparticles. The...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CHEN CHIACHUN, SU WUCHOU, SHIEH DARBIN, CHEN HAIWEN, TSAI TSUNGLIN
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A pharmaceutical composition includes one or a plurality of metal nanoparticles and therapeutic agent. Each of the metal nanoparticles includes a core and a stabilizing agent covering the surface of the core. The therapeutic agent is attached to the stabilizing agent of the metal nanoparticles. The therapeutic agent is an amphiphilic compound and has at least one hydrophobic chain interacting withthe stabilizing agent. The pharmaceutical composition may further include a polymer shell encapsulating the metal nanoparticles and the therapeutic agent for enabling controlled release of the therapeutic agent. The pharmaceutical compositions are bifunctional and may be used for diagnosing and treating cancer. A preparing method utilizing the pharmaceutical composition and uses of the composition are also provided. 本发明提供种药物组合物包括个或多个金属纳米颗粒及治疗剂。每金属纳米颗粒包括内核及包覆于所述内核的表面的稳定剂。所述治疗剂与金属纳米颗粒上的稳定剂结合。所述治疗剂是两亲化合物,每治疗剂具有至少个与所述稳定剂相互作用的疏水链。所述药物组合物可进步包括包封金属纳米颗粒和治疗剂的聚合物壳,所述聚合物壳用于控制所述治疗剂的释放。所述的药物组合物具有双重功能,可用于诊断及治疗癌症。本发明还提供了种应用该药物组合物的制