Tuberculoproteins interacting with human proteins and application thereof

The invention discloses tuberculoproteins interacting with human proteins and application thereof. The invention provides any one of the applications of human protein SMAD2: (A1), diagnosis of tuberculosis; (A2), preparation of a product for diagnosing tuberculosis. According to the tuberculoprotein interacting with the human protein and the application thereof, by utilizing protein-protein interaction experiment based on MTB mycobacterium tuberculosis aptamer-based proteomics arrays, screening and verification are carried out, and tuberculoproteins Rv2423, Rv3241c, Rv3153, Rv0577, Rv2499c and/or Rv2117 interacting with the human proteins are obtained. The tuberculoproteins can be applied to diagnosis of tuberculosis or regulation of activity of human protein SMAD2. 本发明公开了与人类蛋白SMAD2相互作用的结核蛋白及其应用。本发明提供了人类蛋白SMAD2在如下任中的应用：(A1)诊断结核病；(A2)制备用于诊断结核病的产品。本发明利用基于MTB结核分枝杆菌蛋白质组芯片的蛋白-蛋白互作实验进行筛选和鉴定，获得与人类蛋白SMAD2相互作用的结核蛋白Rv2423、Rv3241c、Rv3153、Rv0577、Rv2499c和/或Rv2117。本发明可用于结核诊断或调节人类蛋白SMAD2活性。