Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins
The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a se...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ZHANG ZONGDE LYU LINGNA CAO TINGMING |
| description | The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a secretory protein from mycobacterium tuberculosis with a human protein chip separately and determiningthe human proteins capable of interacting with the bacterial protein and/or the secretory protein according to the hybridization result. According to the method, the bacterial protein and the secretory protein from the mycobacterium tuberculosis are extracted and are further hybridized with the HuProt human protein chip to obtain specific human proteins, namely 84 human proteins capable of interacting with the tuberculosis proteins, and these specific human proteins can be applied to diagnosis and treatment of tuberculosis.
本发明公开了筛选特异性靶向结核分枝杆菌的人的配体蛋白的方法。本发明提供了种筛选能够与结核蛋白相互作用的人类蛋白的方法，包括如下步骤：将来源于结核分枝杆菌的菌体蛋白和分泌蛋白分别与人类蛋白芯 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN108918890A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN108918890A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN108918890A3</originalsourceid><addsrcrecordid>eNqNyjEOgkAQBVAaC6PeYTwACcQGS0M0NlqZWJJl-MAksLvZmS28vY0HsHrN2xbvB2wOA40hkXICvPiJNIJlFKb1w6F3bEiSV7LcI3FegoqW5tIEw0BzXp2nRSbnB4opGMTrvtiMblEcfu6K4-36au8lYuig0TE8rGufddWc66Y5V5fTP-cL4t47Ew</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins</title><source>esp@cenet</source><creator>ZHANG ZONGDE ; LYU LINGNA ; CAO TINGMING</creator><creatorcontrib>ZHANG ZONGDE ; LYU LINGNA ; CAO TINGMING</creatorcontrib><description>The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a secretory protein from mycobacterium tuberculosis with a human protein chip separately and determiningthe human proteins capable of interacting with the bacterial protein and/or the secretory protein according to the hybridization result. According to the method, the bacterial protein and the secretory protein from the mycobacterium tuberculosis are extracted and are further hybridized with the HuProt human protein chip to obtain specific human proteins, namely 84 human proteins capable of interacting with the tuberculosis proteins, and these specific human proteins can be applied to diagnosis and treatment of tuberculosis.
本发明公开了筛选特异性靶向结核分枝杆菌的人的配体蛋白的方法。本发明提供了种筛选能够与结核蛋白相互作用的人类蛋白的方法，包括如下步骤：将来源于结核分枝杆菌的菌体蛋白和分泌蛋白分别与人类蛋白芯</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181130&DB=EPODOC&CC=CN&NR=108918890A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181130&DB=EPODOC&CC=CN&NR=108918890A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG ZONGDE</creatorcontrib><creatorcontrib>LYU LINGNA</creatorcontrib><creatorcontrib>CAO TINGMING</creatorcontrib><title>Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins</title><description>The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a secretory protein from mycobacterium tuberculosis with a human protein chip separately and determiningthe human proteins capable of interacting with the bacterial protein and/or the secretory protein according to the hybridization result. According to the method, the bacterial protein and the secretory protein from the mycobacterium tuberculosis are extracted and are further hybridized with the HuProt human protein chip to obtain specific human proteins, namely 84 human proteins capable of interacting with the tuberculosis proteins, and these specific human proteins can be applied to diagnosis and treatment of tuberculosis.
本发明公开了筛选特异性靶向结核分枝杆菌的人的配体蛋白的方法。本发明提供了种筛选能够与结核蛋白相互作用的人类蛋白的方法，包括如下步骤：将来源于结核分枝杆菌的菌体蛋白和分泌蛋白分别与人类蛋白芯</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOgkAQBVAaC6PeYTwACcQGS0M0NlqZWJJl-MAksLvZmS28vY0HsHrN2xbvB2wOA40hkXICvPiJNIJlFKb1w6F3bEiSV7LcI3FegoqW5tIEw0BzXp2nRSbnB4opGMTrvtiMblEcfu6K4-36au8lYuig0TE8rGufddWc66Y5V5fTP-cL4t47Ew</recordid><startdate>20181130</startdate><enddate>20181130</enddate><creator>ZHANG ZONGDE</creator><creator>LYU LINGNA</creator><creator>CAO TINGMING</creator><scope>EVB</scope></search><sort><creationdate>20181130</creationdate><title>Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins</title><author>ZHANG ZONGDE ; LYU LINGNA ; CAO TINGMING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108918890A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG ZONGDE</creatorcontrib><creatorcontrib>LYU LINGNA</creatorcontrib><creatorcontrib>CAO TINGMING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG ZONGDE</au><au>LYU LINGNA</au><au>CAO TINGMING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins</title><date>2018-11-30</date><risdate>2018</risdate><abstract>The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a secretory protein from mycobacterium tuberculosis with a human protein chip separately and determiningthe human proteins capable of interacting with the bacterial protein and/or the secretory protein according to the hybridization result. According to the method, the bacterial protein and the secretory protein from the mycobacterium tuberculosis are extracted and are further hybridized with the HuProt human protein chip to obtain specific human proteins, namely 84 human proteins capable of interacting with the tuberculosis proteins, and these specific human proteins can be applied to diagnosis and treatment of tuberculosis.
本发明公开了筛选特异性靶向结核分枝杆菌的人的配体蛋白的方法。本发明提供了种筛选能够与结核蛋白相互作用的人类蛋白的方法，包括如下步骤：将来源于结核分枝杆菌的菌体蛋白和分泌蛋白分别与人类蛋白芯</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN108918890A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A14%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHANG%20ZONGDE&rft.date=2018-11-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN108918890A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |