Method for screening specific mycobacterium tuberculosis-targeted human ligand proteins

The invention discloses a method for screening specific mycobacterium tuberculosis-targeted human ligand proteins and provides a method for screening human proteins capable of interacting with tuberculosis proteins. The method comprises the following steps of hybridizing a bacterial protein and a secretory protein from mycobacterium tuberculosis with a human protein chip separately and determiningthe human proteins capable of interacting with the bacterial protein and/or the secretory protein according to the hybridization result. According to the method, the bacterial protein and the secretory protein from the mycobacterium tuberculosis are extracted and are further hybridized with the HuProt human protein chip to obtain specific human proteins, namely 84 human proteins capable of interacting with the tuberculosis proteins, and these specific human proteins can be applied to diagnosis and treatment of tuberculosis. 本发明公开了筛选特异性靶向结核分枝杆菌的人的配体蛋白的方法。本发明提供了种筛选能够与结核蛋白相互作用的人类蛋白的方法，包括如下步骤：将来源于结核分枝杆菌的菌体蛋白和分泌蛋白分别与人类蛋白芯