Solid-phase synthesis process of rizatriptan benzoate intermediate

The invention relates to a solid-phase synthesis process of a rizatriptan benzoate intermediate. The solid-phase synthesis process comprises the steps of directly carrying out solid-phase grinding reaction on 4-nitrobenzyl halide and triazole, after the reaction is finished, adding the mixture into...

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Bibliographische Detailangaben
Hauptverfasser: SUO ZHENGUI, XIANG YULIAN, ZHOU HAITAO
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a solid-phase synthesis process of a rizatriptan benzoate intermediate. The solid-phase synthesis process comprises the steps of directly carrying out solid-phase grinding reaction on 4-nitrobenzyl halide and triazole, after the reaction is finished, adding the mixture into a solvent so as to dissolve a catalyst, and carrying out solid-liquid separation, so as to obtain 4-nitrobenzyl triazole or a derivative of 4-nitrobenzyl triazole, wherein the catalyst is one or more of sodium carbonate, potassium carbonate, sodium hydroxide or potassium hydroxide, and the solid-phase reaction temperature is the room temperature. Compared with the prior art, the solid-phase synthesis process has the advantages that an organic solvent is not used; the solid-phase synthesis process has the characteristics of relatively low energy consumption, relatively low pollutant emission amount and the like, is an environment-friendly, clean and efficient method and has very good industrial development and appli