Novel muramyl peptide derivative compound, synthesis and uses thereof

The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof; (Formula VIII) wherein R1 and R2 both are hydrogen; or R1 is hydrogen and R2 is alkyl or aryl; or R1 is alkyl or aryl and R2 is hydrogen; or R1 and R2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. Thesecompounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants invaccines. 本发明涉及结构式-VIII的新颖的胞壁酰二肽(MDP)衍生物化合物、用于其合成的工艺、在其合成中使用的中间体及其用途；其中R和R两者均是氢；或R是氢并且R是烷基或芳基；或R是烷基或芳基并且R是氢；或R和R两者均是烷基或芳基(相同或不同的基团)；其中烷基基团构成具有或不具有杂原子的C1-C6烷基或更高级的烷基(直链的和支链的两者)；并且芳基基团构成苯基、被取代的苯基、杂芳基、芳基烷基和多核芳族化合物。这些化合物具有优良的药理学性质