Clindamycin phosphate preparation method

The invention discloses a clindamycin phosphate preparation method. The method sequentially includes steps: adopting clindamycin 3,4-isopropylidene as a raw material, performing reaction with dibenzoxycarbonyl phosphoryl chloride, hydrogenating to remove a benzyl protection group, and finally hydrolyzing under an acidic condition to obtain a product of clindamycin phosphate. Extensive and sufficient material sources, low cost, mild reaction conditions and simple process are realized, each reaction step is conventional in operation, difficulty in purification due to adoption of low-selectivityphosphorus oxychloride is avoided, and a wide application range is realized. 本发明公开了种制备克林霉素磷酸酯的方法，该方法依次包括如下步骤：采用丙叉克林霉素为原料，与二苄氧羰基磷酰氯反应，再通过氢化脱去苄基保护基，最后在酸性条件下水解得到产品克林霉素磷酸酯，本发明所用原料来源广泛充足，价格便宜、反应条件温和、工艺简洁，各步反应均为常规操作，避免了使用选择性较低的三氯氧磷带来的纯化困难，有较好的应用范围。