Nanometer magnetic particles covered with erythrocyte membranes, and preparation method and uses thereof

The invention provides nanometer magnetic particles covered with erythrocytes, particularly nanometer magnetic particles covered with erythrocyte membranes, and a preparation method and uses thereof.The invention also provides the uses of the nanometer magnetic particles in preparation of a myocardi...

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Bibliographische Detailangaben
Hauptverfasser: GU CHANGGUO, DUAN JIACHUAN, FAN YUANQIAO, FAN DAIMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides nanometer magnetic particles covered with erythrocytes, particularly nanometer magnetic particles covered with erythrocyte membranes, and a preparation method and uses thereof.The invention also provides the uses of the nanometer magnetic particles in preparation of a myocardial infarction animal model. The myocardial infarction animal model is of great value for myocardialinfarction prevention, diagnosis and treatment. Thinking outside a traditional train of thought of preparing myocardial infarction animal models through surgical operation coronary artery ligation, magnetic-carrier artificial erythrocytes are constructed and fed back into an animal body, and local aggregation of the magnetic-carrier artificial erythrocytes is controlled by an external magnetic field to cause local vessel obstruction of heart so as to induce local myocardial infarction. Major trauma caused by blood vessel ligation is completely avoided, and the animal model which can truly simulate a myocardial infarct