HIV ANTIBODY DERIVATIVES WITH DUAL ANTIVIRAL AND IMMUNOMODULATORY ACTIVITY

The present invention relates to antibody derivatives against HIV based on a mutated CD4-lgG scaffold with enhanced antiviral and immunomodulatory activities. These antibody derivatives comprise a gp41-derived polypeptide and optionally a human CCR5 receptor sequence. They are characterized for having an increased ability to (i) block the entry of human immunodeficiency virus (HIV) into host cellsand (ii) elicit effector functions through the activation of natural killer (NK) cells. The present invention further relates to nucleic acids, vectors and host cells expressing said antibody derivatives, as well their therapeutic and diagnostic applications in human health. 本发明涉及基于突变型CD4-IgG骨架的针对HIV的抗体衍生物，其具有增强的抗病毒和免疫调节活性。这些抗体衍生物包括gp41衍生的多肽和任选的人类CCR5受体序列。这些抗体衍生物的特征为具有提高的(i)阻碍人类免疫缺陷病毒(HIV)进入宿主细胞和(ii)经由自然杀手(NK)细胞的活化引发效应功能的能力。本发明进步涉及表达所述抗体衍生物的核酸、载体和宿主细胞，以及其在人体健康中的治疗性及诊断性应用。