METHOD FOR PRESSURE CONTROL IN CROSSFLOW FILTRATION

The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising apump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a len...

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Hauptverfasser: HV BASHKAR, NUTALAPATI SASI KUMAR, VERNEKAR AJIT S, KARMARKAR NACHIKET, GEBAUER KLAUS, ARUMUGAM SASIKUMAR, MOHAN PRASHANTH HOSABETTU, HEGDE SHASHIDHAR, MYGAPULA SUDHEER, HINDUPUR SAMEERA SIMHA, MAIYA NITYANANDA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising apump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve,a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump;b) pumping a liquid with t