Compounds and use thereof in anti-AML drugs
The present invention relates to the field of medicinal chemistry, discloses compounds and use thereof in anti-AML drugs, and specifically relates to imidazole ring-substituted thiophenic compounds, preparation method thereof, pharmaceutical compositions containing the compounds, and medical use of...
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| creator | XIANG LI HENG HAO CHEN YADONG QIN TIANREN LU SHUAI WANG ZHIJIE TIAN JIEYI ZHI YANLE CAI JIONGHENG LU TAO |
| description | The present invention relates to the field of medicinal chemistry, discloses compounds and use thereof in anti-AML drugs, and specifically relates to imidazole ring-substituted thiophenic compounds, preparation method thereof, pharmaceutical compositions containing the compounds, and medical use of the compounds, particularly use of the compounds as an ITD mutant selective inhibitor of FMS-like tyrosine kinase 3.
本发明涉及药物化学领域，公开了类化合物及其在抗AML药物中的用途。具体涉及唑环取代噻吩类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3的ITD突变型选择性抑制剂的用途。 |
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本发明涉及药物化学领域，公开了类化合物及其在抗AML药物中的用途。具体涉及唑环取代噻吩类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3的ITD突变型选择性抑制剂的用途。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181023&DB=EPODOC&CC=CN&NR=108690006A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181023&DB=EPODOC&CC=CN&NR=108690006A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIANG LI</creatorcontrib><creatorcontrib>HENG HAO</creatorcontrib><creatorcontrib>CHEN YADONG</creatorcontrib><creatorcontrib>QIN TIANREN</creatorcontrib><creatorcontrib>LU SHUAI</creatorcontrib><creatorcontrib>WANG ZHIJIE</creatorcontrib><creatorcontrib>TIAN JIEYI</creatorcontrib><creatorcontrib>ZHI YANLE</creatorcontrib><creatorcontrib>CAI JIONGHENG</creatorcontrib><creatorcontrib>LU TAO</creatorcontrib><title>Compounds and use thereof in anti-AML drugs</title><description>The present invention relates to the field of medicinal chemistry, discloses compounds and use thereof in anti-AML drugs, and specifically relates to imidazole ring-substituted thiophenic compounds, preparation method thereof, pharmaceutical compositions containing the compounds, and medical use of the compounds, particularly use of the compounds as an ITD mutant selective inhibitor of FMS-like tyrosine kinase 3.
本发明涉及药物化学领域，公开了类化合物及其在抗AML药物中的用途。具体涉及唑环取代噻吩类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3的ITD突变型选择性抑制剂的用途。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB2zs8tyC_NSylWSMxLUSgtTlUoyUgtSs1PU8jMAwqVZOo6-voopBSVphfzMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DAwszSwMDAzNHY2LUAAAW6yii</recordid><startdate>20181023</startdate><enddate>20181023</enddate><creator>XIANG LI</creator><creator>HENG HAO</creator><creator>CHEN YADONG</creator><creator>QIN TIANREN</creator><creator>LU SHUAI</creator><creator>WANG ZHIJIE</creator><creator>TIAN JIEYI</creator><creator>ZHI YANLE</creator><creator>CAI JIONGHENG</creator><creator>LU TAO</creator><scope>EVB</scope></search><sort><creationdate>20181023</creationdate><title>Compounds and use thereof in anti-AML drugs</title><author>XIANG LI ; HENG HAO ; CHEN YADONG ; QIN TIANREN ; LU SHUAI ; WANG ZHIJIE ; TIAN JIEYI ; ZHI YANLE ; CAI JIONGHENG ; LU TAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108690006A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XIANG LI</creatorcontrib><creatorcontrib>HENG HAO</creatorcontrib><creatorcontrib>CHEN YADONG</creatorcontrib><creatorcontrib>QIN TIANREN</creatorcontrib><creatorcontrib>LU SHUAI</creatorcontrib><creatorcontrib>WANG ZHIJIE</creatorcontrib><creatorcontrib>TIAN JIEYI</creatorcontrib><creatorcontrib>ZHI YANLE</creatorcontrib><creatorcontrib>CAI JIONGHENG</creatorcontrib><creatorcontrib>LU TAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XIANG LI</au><au>HENG HAO</au><au>CHEN YADONG</au><au>QIN TIANREN</au><au>LU SHUAI</au><au>WANG ZHIJIE</au><au>TIAN JIEYI</au><au>ZHI YANLE</au><au>CAI JIONGHENG</au><au>LU TAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compounds and use thereof in anti-AML drugs</title><date>2018-10-23</date><risdate>2018</risdate><abstract>The present invention relates to the field of medicinal chemistry, discloses compounds and use thereof in anti-AML drugs, and specifically relates to imidazole ring-substituted thiophenic compounds, preparation method thereof, pharmaceutical compositions containing the compounds, and medical use of the compounds, particularly use of the compounds as an ITD mutant selective inhibitor of FMS-like tyrosine kinase 3.
本发明涉及药物化学领域，公开了类化合物及其在抗AML药物中的用途。具体涉及唑环取代噻吩类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3的ITD突变型选择性抑制剂的用途。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compounds and use thereof in anti-AML drugs |
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