Compounds and use thereof in anti-AML drugs

The present invention relates to the field of medicinal chemistry, discloses compounds and use thereof in anti-AML drugs, and specifically relates to imidazole ring-substituted thiophenic compounds, preparation method thereof, pharmaceutical compositions containing the compounds, and medical use of the compounds, particularly use of the compounds as an ITD mutant selective inhibitor of FMS-like tyrosine kinase 3. 本发明涉及药物化学领域，公开了类化合物及其在抗AML药物中的用途。具体涉及唑环取代噻吩类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3的ITD突变型选择性抑制剂的用途。