Synthetic method of nitrile compound containing unsaturated bond

The invention relates to a synthetic method of a compound as shown in the formula (3) in the specification. The synthetic method comprises the following steps: a compound as shown in the formula (1) and a compound as shown in the formula (2) react in an organic solvent in the presence of a palladium...

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Bibliographische Detailangaben
Hauptverfasser: CHEN JIUXI, ZHEN QIANQIAN, HU KUN, SHAO YINLIN, XU TONG, CHENG TIANXING, YE PENGQING, YU SHULING, ZHANG YETONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a synthetic method of a compound as shown in the formula (3) in the specification. The synthetic method comprises the following steps: a compound as shown in the formula (1) and a compound as shown in the formula (2) react in an organic solvent in the presence of a palladium catalyst, an organic ligand, an oxidizing agent and an acidic compound, and postprocessing is carried out after the reaction so as to obtain the compound as shown in the formula (3), wherein R1 is selected from H, halogen, C1-C6 alkyl group, halogenated C1-C6 alkyl, C1-C6 alkyloxy or halogenated C1-C6 alkyloxy. Through use of a unique comprehensive reaction system (including selection and combination of the catalyst, the organic ligand, the acidic compound, the organic solvent and the like), agood technical effect is achieved. The synthetic method of the invention has good application base and research value. 本发明涉及种下式(3)化合物的合成方法,