Amide arylpiperazine derivative and preparation method and application thereof

The invention belongs to the technical field of pharmaceutical chemistry, particularly relates to an amide arylpiperazine derivative and further discloses a preparation method and application of the amide arylpiperazine derivative to preparation of medicines for treating benign prostatic hyperplasia. According to primary pharmacological researches on the amide arylpiperazine derivative and pharmaceutically acceptable salts, the derivative shows high antagonistic activity and selectivity on alpha1A-AR and alpha1D-AR but weak alpha1B subtype antagonistic activity in biological functional tests of rat in-vitro tissues (such as spleen, thoracic aorta and sperm duct), and accordingly medicinal side effects can be effectively reduced while medicinal curative effects are guaranteed, and efficientand safe options can be provided for research and development of novel medicines for benign prostatic hyperplasia. 本发明属于药物化学技术领域，具体涉及种酰胺类芳基哌嗪衍生物，并进步公开其制备方法，以及用于制备治疗良性前列腺增生药物的应用。本发明所述的酰胺类芳基哌嗪衍生物及其药学上可接受的盐，经初步药理学研究，通过大鼠离体组织(脾、