Preparation method of anti-tumor targeted therapeutic drug tivozanib intermediate

The invention belongs to the technical field of chemical drug preparation, and particularly relates to a preparation method of an anti-tumor targeted therapeutic drug tivozanib intermediate. Attapulgite serves as a carrier for loading Cu (I) salt, nickel chloride hexahydrate and KF are used for modification to obtain a high-selectivity nanoparticle catalyst. The nanoparticle catalyst can catalyze4-chlorine-6, 7-dimethoxy-quinoline and 4-amino-3-chlorophenol hydrochloride to prepare 4-(4-amino-3-chlorobenzene oxygen group)-6, 7-dimethoxy quinoline, the process is high in yield, and the shortcomings of low yield and high production temperature of an existing process are overcome. Moreover, the nanoparticle catalyst is good in universality, can be used for catalyzing other chlorobenzene andphenol derivatives to generate diphenyl ether derivatives, and can be used for preparing fine chemical intermediates. 本发明属于化学药制备技术领域，具体涉及种抗肿瘤靶向治疗药物tivozanib中间体的制备方法。本发明以阿塔凝胶为载体，对Cu(I)盐进行负载，利用六水合氯化镍和KF进行改性，获得高选择性的纳米微球催化剂。本发明获得的