Preparation method and device of micro-fluidic dual-aqueous-phase monodisperse calcium alginate microspheres

The invention discloses a preparation method of micro-fluidic dual-aqueous-phase monodisperse calcium alginate microspheres. The preparation method comprises the following steps: taking a polyethyleneglycol water solution as an outer aqueous phase, and glucan and a sodium alginate water solution as an inner aqueous phase; generating dual-aqueous-phase sodium alginate liquid drops at a conical sharp point through a coaxial capillary tube device; wherein the outer aqueous phase is continuous sample feeding; the inner aqueous phase is periodicity and intermittence sample feeding; introducing thedual-aqueous-phase sodium alginate liquid drops into a calcium chloride water solution to generate the needed monodisperse calcium alginate microspheres. According to the preparation method disclosedby the invention, sodium alginate or dual aqueous phases do not need to be subjected to a complicated pre-treatment process and a production manner is simple and rapid and has good biocompatibility;the formed microspheres are