Osteoprotegerin supported sustained release nanoparticle, and preparation method and application thereof

The invention relates to the field of biomedical science, and concretely relates to an osteoprotegerin supported sustained release nanoparticle, and a preparation method and an application thereof. The osteoprotegerin supported sustained release nanoparticle is prepared from osteoprotegerin, maleimide-polyethylene glycol-polycaprolactone and polycaprolactone. The invention also provides the preparation method of the osteoprotegerin supported sustained release nanoparticle. The osteoprotegerin supported sustained release nanoparticle is prepared through performing ultrasonic treatment with a mixture formed by the osteoprotegerin, maleimide-polyethylene glycol-polycaprolactone, polycaprolactone and an organic solvent as an oil phase and an aqueous solution of a water-soluble polymer as an aqueous phase. The osteoprotegerin is encapsulated in a nanoparticle to construct a nano-drug supported controlled release system to make the osteoprotegerin slowly released locally from the nanoparticle at a certain rate, so